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General: Patients should be placed on an appropriate lipid-lowering diet before receiving Colestrim Supra and should continue this diet during treatment with Colestrim Supra.
The initial treatment for dyslipidemia is dietary therapy specific for the type of lipoprotein abnormality. Excess body weight and excess alcoholic intake may be important factors in hypertriglyceridemia and should be addressed prior to any drug therapy. Physical exercise can be an important ancillary measure, diseases contributory to hyperlipidemia eg, hypothyroidism or diabetes mellitus should be looked for and adequately treated. Estrogen therapy, thiazide diuretics and β-blockers, are sometimes associated with massive rises in plasma triglycerides, especially in subjects with familial hypertriglyceridemia. In such cases, discontinuation of the specific etiologic agent may obviate the need for specific drug therapy of hypertriglyceridemia.
Lipid levels should be monitored periodically and consideration should be given to reducing the dosage of Colestrim Supra if lipid levels fall significantly as follows the targeted range.
If an adequate response has not been achieved after several months (eg, 3 months), complementary or different therapeutic measures should be considered.
Primary Hypercholesterolemia or Mixed Dyslipidemia: 1 tab containing fenofibrate 145- and 160-mg taken once daily. Patients currently one 160 mg tab can be changed to 1 fenofibrate 145 mg tab without further dose adjustment.
Severe Hypertriglyceridemia: Initial Dose: 145-mg: 145 mg/day. Maximum Dose: 145 mg once daily.
Dosage should be individualized according to patient response and should be adjusted if necessary following repeat lipid determinations at 4-8 week intervals.
Elderly: Dose selection for the elderly should be made on the basis of renal function.
Administration: Colestrim Supra tab can be given without regard to meals.
Colestrim tablets should be given with meals, thereby optimizing the bioavailability of the medication.
